烈祝賀老師訂購我司ELISA試劑盒，SIC文章發表成功!發表期刊WJG.
更新時間：2024-08-13 點擊次數：158次烈祝賀老師訂購我司ELISA試劑盒，SIC文章發表成功!發表期刊WJG.
WJG在眾多消化類期刊中惟一進入SCI-E行列-美國科學情報研究所(Institute for Scientific Information,ISI)2000年度《期刊引用報告》WJG全稱是世界胃腸病雜志，被SCI收錄了。
文章標題：
P-selectin glycoprotein ligand 1 deficiency prevents development of acute pancreatitis by attenuating leukocyte infiltration
摘要：BACKGROUND Acute pancreatitis(AP) is rapid-onset pancreatic inflammation that causes local and systemic inflammatory response syndrome(SIRS) with high morbidity and mortality, but no approved therapies are currently available. P-selectin glycoprotein ligand 1(PSGL-1) is a transmembrane glycoprotein to initiate inflammatory responses. We hypothesized that PSGL-1 may be involved in the development of AP and would be a new target for the treatment of AP.AIM To investigate the role and mechanism of PSGL-1 in the development of AP.METHODS The PSGL-1 expression on leukocytes was detected in peripheral blood of AP patients and volunteers. Pancreatic injury, inflammatory cytokines expression, and inflammatory cell infiltration was measured in AP mouse models induced with PSGL-1 knockout(PSGL-1-/-) and wild-type(PSGL-1+/+) mice. Leukocyteendothelial cell adhesion was measured in a peripheral blood mononuclear cell(PBMC)-endothelial cell coculture system.RESULTS The expression of PSGL-1 on monocytes and neutrophils was significantly incre
文章中使用我司試劑盒為：IL-1beta elisa kit IL-6 elisa kit
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